| 1. Round | 17/01/2021 | Deportes Quindío | - | Valledupar FC | 1:2 | ||||
| 2. Round | 23/01/2021 | Llaneros FC | - | Deportes Quindío | 0:1 | ||||
| 3. Round | 31/01/2021 | Deportes Quindío | - | Unión Magdalena | 1:0 | ||||
| 5. Round | 10/02/2021 | Orsomarso SC | - | Deportes Quindío | 2:1 | ||||
| 10. Round | 07/03/2021 | Deportes Quindío | - | Fortaleza FC | 2:1 |
Colombia