| 6. Round | 25/09/2021 | KAA Gent [U18] | - | Club Brugge KV [U18] | 2:2 | ||||
| 8. Round | 09/10/2021 | Cercle Brugge [U18] | - | Club Brugge KV [U18] | 4:3 | ||||
| 9. Round | 16/10/2021 | Club Brugge KV [U18] | - | KRC Genk [U18] | 5:3 | ||||
| 10. Round | 23/10/2021 | Royal Antwerp FC [U18] | - | Club Brugge KV [U18] | 0:2 | ||||
| 13. Round | 20/11/2021 | Club Brugge KV [U18] | - | KVC Westerlo [U18] | 4:2 | ||||
| 14. Round | 27/11/2021 | Club Brugge KV [U18] | - | Sint-Truidense VV [U18] | 2:0 | ||||
| 15. Round | 15/01/2022 | Standard Liège [U18] | - | Club Brugge KV [U18] | 0:1 |  |
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| 16. Round | 22/01/2022 | KV Mechelen [U18] | - | Club Brugge KV [U18] | 1:4 | ||||
| 19. Round | 12/02/2022 | Club Brugge KV [U18] | - | SV Zulte Waregem [U18] | 3:0 | ||||
| 17. Round | 16/02/2022 | Club Brugge KV [U18] | - | KAA Gent [U18] | 6:2 | ||||
| 21. Round | 05/03/2022 | Club Brugge KV [U18] | - | Cercle Brugge [U18] | 4:3 | ||||
| 25. Round | 02/04/2022 | Club Brugge KV [U18] | - | RSC Anderlecht [U18] | 3:1 | ||||
| 22. Round | 23/04/2022 | KRC Genk [U18] | - | Club Brugge KV [U18] | 4:1 | ||||
| 26. Round | 30/04/2022 | KVC Westerlo [U18] | - | Club Brugge KV [U18] | 1:4 |
Belgium