| 15. Round | 09/07/2021 | Galway United | - | Cobh Ramblers | 2:0 | ||||
| 16. Round | 16/07/2021 | Bray Wanderers | - | Galway United | 0:0 | ||||
| 21. Round | 03/09/2021 | Cabinteely FC | - | Galway United | 0:1 | ||||
| 22. Round | 10/09/2021 | Galway United | - | Treaty United | 0:0 | ||||
| 23. Round | 24/09/2021 | Galway United | - | UC Dublin | 4:1 | ||||
| 24. Round | 01/10/2021 | Cobh Ramblers | - | Galway United | 0:1 | ||||
| 26. Round | 15/10/2021 | Galway United | - | Wexford FC | 2:1 | ||||
| 25. Round | 22/10/2021 | Galway United | - | Bray Wanderers | 1:0 |  |
Ireland