| 1. Round | 16/09/2000 | Paniliakos Pyrgos | - | Panionios GSS | 1:1 | ||||
| 2. Round | 22/09/2000 | Panionios GSS | - | Panathinaikos | 0:2 | ||||
| 3. Round | 01/10/2000 | PAOK Saloniki | - | Panionios GSS | 1:1 |  |
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| 4. Round | 28/10/2000 | Panionios GSS | - | Skoda Xanthi | 0:0 | ||||
| 5. Round | 04/11/2000 | Panionios GSS | - | Iraklis Saloniki | 1:1 | |
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| 6. Round | 10/11/2000 | Athinaikos | - | Panionios GSS | 2:0 | |
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| 13. Round | 06/01/2001 | Olympiakos Piraeus | - | Panionios GSS | 2:0 | ||||
| 18. Round | 11/02/2001 | Panionios GSS | - | PAOK Saloniki | 1:1 | ||||
| 19. Round | 17/02/2001 | Skoda Xanthi | - | Panionios GSS | 3:1 |
Liberia