| 1. Round | 01/08/2021 | Luis Ángel Firpo | - | Jocoro FC | 1:1 | ||||
| 2. Round | 08/08/2021 | Municipal Limeño | - | Luis Ángel Firpo | 1:1 | ||||
| 3. Round | 11/08/2021 | Luis Ángel Firpo | - | Platense Zacatecoluca | 3:2 | ||||
| 4. Round | 15/08/2021 | Alianza | - | Luis Ángel Firpo | 2:2 | ||||
| 5. Round | 21/08/2021 | AD Chalatenango | - | Luis Ángel Firpo | 0:2 | ||||
| 6. Round | 25/08/2021 | Luis Ángel Firpo | - | Once Municipal | 2:2 | ||||
| 7. Round | 29/08/2021 | FAS | - | Luis Ángel Firpo | 3:1 | ||||
| 15. Round | 24/10/2021 | Luis Ángel Firpo | - | Alianza | 2:1 | ||||
| 18. Round | 07/11/2021 | Luis Ángel Firpo | - | FAS | 2:0 | ||||
| 19. Round | 14/11/2021 | Isidro Metapán | - | Luis Ángel Firpo | 2:1 | ||||
| 20. Round | 18/11/2021 | Luis Ángel Firpo | - | Atlético Marte | 2:0 | ||||
| 21. Round | 21/11/2021 | Santa Tecla FC | - | Luis Ángel Firpo | 2:2 | ||||
| 22. Round | 27/11/2021 | Luis Ángel Firpo | - | CD Águila | 1:0 |
Mexico