| 5. Round | 21/08/2021 | AD Chalatenango | - | Luis Ángel Firpo | 0:2 |  |
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| 6. Round | 26/08/2021 | CD Águila | - | AD Chalatenango | 2:1 | |
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| 8. Round | 11/09/2021 | Jocoro FC | - | AD Chalatenango | 3:1 | ||||
| 9. Round | 16/09/2021 | AD Chalatenango | - | FAS | 1:2 | |
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| 10. Round | 19/09/2021 | AD Chalatenango | - | Municipal Limeño | 1:1 | ||||
| 18. Round | 07/11/2021 | Once Municipal | - | AD Chalatenango | 1:2 | ||||
| 19. Round | 14/11/2021 | AD Chalatenango | - | Jocoro FC | 2:0 | |
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| 20. Round | 17/11/2021 | FAS | - | AD Chalatenango | 1:1 | |
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| 22. Round | 27/11/2021 | AD Chalatenango | - | Isidro Metapán | 1:0 |
El Salvador