| 5. Round | 01/05/2022 | Alianza Universidad | - | Santos FC | 4:1 | ||||
| 7. Round | 15/05/2022 | Unión Comercio | - | Santos FC | 3:1 | ||||
| 10. Round | 05/06/2022 | Santos FC | - | Chavelines Juniors | 3:0 | ||||
| 11. Round | 11/06/2022 | Pirata | - | Santos FC | 0:1 | ||||
| 12. Round | 19/06/2022 | Santos FC | - | Llacuabamba | 2:2 |  |
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| 13. Round | 26/06/2022 | Los Chankas | - | Santos FC | 2:0 |
Peru