| 1. Round | 14/10/2000 | Brisbane Strikers | - | Melbourne Knights | 1:2 | ||||
| 2. Round | 22/10/2000 | Melbourne Knights | - | Parramatta Power | 2:1 | ||||
| 3. Round | 28/10/2000 | Canberra Cosmos | - | Melbourne Knights | 3:0 | ||||
| 8. Round | 03/12/2000 | Melbourne Knights | - | Eastern Pride | 2:1 | ||||
| 9. Round | 08/12/2000 | Auckland Football Kingz | - | Melbourne Knights | 2:2 | ||||
| 10. Round | 17/12/2000 | Melbourne Knights | - | Northern Spirit | 1:1 | ||||
| 19. Round | 17/02/2001 | Wollongong City Wolves | - | Melbourne Knights | 5:2 | ||||
| 20. Round | 23/02/2001 | Melbourne Knights | - | South Melbourne Lakers | 4:0 | ||||
| 21. Round | 04/03/2001 | Sydney United Pumas | - | Melbourne Knights | 0:1 | ||||
| 22. Round | 09/03/2001 | Melbourne Knights | - | Sydney Olympic Lions | 2:3 | ||||
| 24. Round | 25/03/2001 | Melbourne Knights | - | Auckland Football Kingz | 2:2 |  |
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| 25. Round | 30/03/2001 | Northern Spirit | - | Melbourne Knights | 1:4 | ||||
| 27. Round | 14/04/2001 | Perth Glory | - | Melbourne Knights | 1:0 | ||||
| 29. Round | 25/04/2001 | Marconi-Fairfield Stallions | - | Melbourne Knights | 0:0 | ||||
| 30. Round | 29/04/2001 | Melbourne Knights | - | Newcastle United | 6:4 |
Australia