| 3. Round | 26/08/2000 | KV Mechelen | - | Excelsior Mouscron | 1:5 | ||||
| 4. Round | 06/09/2000 | Sporting Lokeren | - | KV Mechelen | 3:2 | ||||
| 6. Round | 16/09/2000 | RAA La Louviére | - | KV Mechelen | 2:2 | ||||
| 7. Round | 23/09/2000 | KV Mechelen | - | Germinal Beerschot | 2:3 | ||||
| 10. Round | 22/10/2000 | KV Mechelen | - | K.S.C. Eendracht Aalst | 4:1 | ||||
| 12. Round | 11/11/2000 | KV Mechelen | - | KVC Westerlo | 0:1 | ||||
| 13. Round | 18/11/2000 | KSK Beveren | - | KV Mechelen | 1:1 | ||||
| 14. Round | 25/11/2000 | KV Mechelen | - | RSC Charleroi | 4:3 | ||||
| 15. Round | 02/12/2000 | Royal Antwerp FC | - | KV Mechelen | 3:1 | ||||
| 16. Round | 09/12/2000 | KV Mechelen | - | RSC Anderlecht | 0:2 |  |
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| 17. Round | 16/12/2000 | Lierse SK (old) | - | KV Mechelen | 1:1 | ||||
| 18. Round | 20/12/2000 | KRC Genk | - | KV Mechelen | 3:1 | ||||
| 19. Round | 20/01/2001 | KV Mechelen | - | KAA Gent | 3:3 | ||||
| 20. Round | 28/01/2001 | Excelsior Mouscron | - | KV Mechelen | 4:2 | ||||
| 21. Round | 03/02/2001 | KV Mechelen | - | Sporting Lokeren | 0:3 | ||||
| 27. Round | 01/04/2001 | K.S.C. Eendracht Aalst | - | KV Mechelen | 1:3 | ||||
| 29. Round | 14/04/2001 | KVC Westerlo | - | KV Mechelen | 0:0 | ||||
| 31. Round | 28/04/2001 | RSC Charleroi | - | KV Mechelen | 4:2 |
Belgium