| 5. Round | 25/08/2021 | Real Cartagena | - | Cortuluá | 2:0 | ||||
| 6. Round | 29/08/2021 | Cortuluá | - | Leones FC | 1:0 | ||||
| 1. Round | 01/09/2021 | Cortuluá | - | Real Santander | 2:0 |  |
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| 7. Round | 04/09/2021 | Llaneros FC | - | Cortuluá | 1:1 | ||||
| 13. Round | 19/10/2021 | Valledupar FC | - | Cortuluá | 1:2 |  |
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| 14. Round | 25/10/2021 | Cortuluá | - | Boyacá Chicó | 0:2 | ||||
| 15. Round | 30/10/2021 | Fortaleza FC | - | Cortuluá | 1:2 |
Colombia