| 4. Round | 08/02/2021 | Valledupar FC | - | Real Cartagena | 2:0 | ||||
| 5. Round | 11/02/2021 | Real Santander | - | Valledupar FC | 0:1 | ||||
| 6. Round | 15/02/2021 | Valledupar FC | - | Bogotá FC | 6:0 | ||||
| 7. Round | 23/02/2021 | Fortaleza FC | - | Valledupar FC | 3:2 |  |
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| 8. Round | 27/02/2021 | Valledupar FC | - | Leones FC | 0:1 | ||||
| 10. Round | 07/03/2021 | Valledupar FC | - | Cortuluá | 1:2 | ||||
| 13. Round | 27/03/2021 | Valledupar FC | - | Tigres FC | 0:0 | ||||
| 14. Round | 05/04/2021 | Llaneros FC | - | Valledupar FC | 2:1 |  |
Colombia