| 1. Round | 25/10/2021 | National Bank SC | - | Tala'ea El Gaish SC | 3:0 | ||||
| 2. Round | 31/10/2021 | Tala'ea El Gaish SC | - | Zamalek | 0:2 | ||||
| 3. Round | 04/11/2021 | Al Mokawloon | - | Tala'ea El Gaish SC | 1:1 | ||||
| 7. Round | 21/12/2021 | Pyramids FC | - | Tala'ea El Gaish SC | 3:0 | ||||
| 10. Round | 21/02/2022 | Tala'ea El Gaish SC | - | Pharco FC | 1:0 | ||||
| 21. Round | 28/05/2022 | Ghazl Al Mehalla | - | Tala'ea El Gaish SC | 0:1 | ||||
| 22. Round | 17/06/2022 | Tala'ea El Gaish SC | - | Smouha Sporting Club | 3:3 |  |
Ghana