| 6. Round | 18/08/2021 | CS Herediano | - | AD San Carlos | 2:0 | ||||
| 7. Round | 26/08/2021 | Santos de Guápiles | - | CS Herediano | 2:1 | ||||
| 8. Round | 29/08/2021 | CS Herediano | - | CS Cartaginés | 2:0 | ||||
| 15. Round | 12/10/2021 | Municipal Pérez Zeledón | - | CS Herediano | 0:1 | ||||
| 16. Round | 17/10/2021 | CS Herediano | - | LD Alajuelense | 0:0 | ||||
| 17. Round | 23/10/2021 | AD San Carlos | - | CS Herediano | 0:0 | ||||
| 18. Round | 28/10/2021 | CS Herediano | - | Santos de Guápiles | 1:1 | ||||
| 22. Round | 28/11/2021 | Sporting FC | - | CS Herediano | 0:2 |  |
Costa Rica