| 1. Round | 26/10/2021 | Al Mokawloon | - | El Sharkia Lel Dokhan | 1:0 |  |
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| 2. Round | 30/10/2021 | ENPPI | - | Al Mokawloon | 3:2 | ||||
| 7. Round | 21/12/2021 | Al Mokawloon | - | Zamalek | 1:2 | ||||
| 15. Round | 18/04/2022 | Pharco FC | - | Al Mokawloon | 1:0 | ||||
| 16. Round | 26/04/2022 | Al Mokawloon | - | Ittihad El Iskandary | 1:1 | ||||
| 17. Round | 01/05/2022 | Al Masry Club | - | Al Mokawloon | 0:2 | ||||
| 18. Round | 09/05/2022 | El Sharkia Lel Dokhan | - | Al Mokawloon | 1:1 | ||||
| 19. Round | 15/05/2022 | Al Mokawloon | - | ENPPI | 2:2 | ||||
| 20. Round | 21/05/2022 | Tala'ea El Gaish SC | - | Al Mokawloon | 1:0 | ||||
| 29. Round | 06/08/2022 | Pyramids FC | - | Al Mokawloon | 1:0 | ||||
| 31. Round | 19/08/2022 | Misr lel-Maqasah SC | - | Al Mokawloon | 0:3 | |
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| 32. Round | 23/08/2022 | Al Mokawloon | - | Pharco FC | 2:0 | |
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| 33. Round | 26/08/2022 | Ittihad El Iskandary | - | Al Mokawloon | 0:1 | ||||
| 34. Round | 30/08/2022 | Al Mokawloon | - | Al Masry Club | 2:1 | |
Nigeria