| 3. Round | 05/05/2012 | CD Chivas | - | Chicago Fire | 1:2 | ||||
| 3. Round | 14/05/2012 | San Jose Earthquakes | - | CD Chivas | 1:1 | ||||
| 3. Round | 27/05/2012 | CD Chivas | - | Seattle Sounders | 1:1 | ||||
| 5. Round | 18/07/2012 | CD Chivas | - | Portland Timbers | 1:0 | ||||
| 5. Round | 29/07/2012 | Portland Timbers | - | CD Chivas | 0:1 | ||||
| 6. Round | 13/08/2012 | CD Chivas | - | Los Angeles Galaxy | 0:4 |  |
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| 6. Round | 19/08/2012 | Colorado Rapids | - | CD Chivas | 1:1 | ||||
| 6. Round | 26/08/2012 | CD Chivas | - | Seattle Sounders | 2:6 | ||||
| 7. Round | 16/09/2012 | CD Chivas | - | San Jose Earthquakes | 0:2 | |
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| 7. Round | 20/09/2012 | Columbus Crew | - | CD Chivas | 1:0 | |
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| 7. Round | 24/09/2012 | D.C. United | - | CD Chivas | 1:0 | ||||
| 7. Round | 30/09/2012 | CD Chivas | - | Real Salt Lake | 0:4 | ||||
| 8. Round | 04/10/2012 | Vancouver Whitecaps | - | CD Chivas | 4:0 | |
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| 8. Round | 21/10/2012 | CD Chivas | - | Colorado Rapids | 0:2 | |
Colombia