| 3. Round | 25/01/2025 | ART Municipal Jalapa | - | Club Deportivo Ocotal | 2:0 | ||||
| 4. Round | 30/01/2025 | Club Deportivo Ocotal | - | Real Estelí FC | 0:2 | ||||
| 5. Round | 02/02/2025 | CD Walter Ferretti | - | Club Deportivo Ocotal | 5:2 | ||||
| 1. Round | 06/02/2025 | Club Deportivo Ocotal | - | Managua FC | 2:3 | ||||
| 11. Round | 08/03/2025 | Matagalpa FC | - | Club Deportivo Ocotal | 3:0 | ||||
| 12. Round | 15/03/2025 | Club Deportivo Ocotal | - | ART Municipal Jalapa | 2:0 | ||||
| 14. Round | 31/03/2025 | Club Deportivo Ocotal | - | CD Walter Ferretti | 2:2 |  |
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| 16. Round | 14/04/2025 | UNAN Managua | - | Club Deportivo Ocotal | 4:0 |  |
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| 13. Round | 17/04/2025 | Real Estelí FC | - | Club Deportivo Ocotal | 3:2 | ||||
| 17. Round | 27/04/2025 | H&H Export Sébaco | - | Club Deportivo Ocotal | 2:1 | |
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| 18. Round | 01/05/2025 | Club Deportivo Ocotal | - | Diriangén FC | 0:2 | |
Argentina