| 1. Round | 01/08/2021 | Alianza | - | Municipal Limeño | 4:1 |  |
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| 2. Round | 08/08/2021 | Platense Zacatecoluca | - | Alianza | 2:2 | ||||
| 4. Round | 15/08/2021 | Alianza | - | Luis Ángel Firpo | 2:2 | |
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| 7. Round | 29/08/2021 | Isidro Metapán | - | Alianza | 1:2 | ||||
| 8. Round | 12/09/2021 | Alianza | - | Atlético Marte | 3:1 |  |
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| 9. Round | 16/09/2021 | Santa Tecla FC | - | Alianza | 0:4 | ||||
| 10. Round | 19/09/2021 | Alianza | - | CD Águila | 2:1 | ||||
| 12. Round | 02/10/2021 | Municipal Limeño | - | Alianza | 0:3 | ||||
| 13. Round | 17/10/2021 | Alianza | - | Platense Zacatecoluca | 4:0 | ||||
| 21. Round | 21/11/2021 | CD Águila | - | Alianza | 0:1 |
El Salvador