| Group B | 18/09/2022 | Alianza | - | Isidro Metapán | 2:2 | ||||
| Group B | 22/09/2022 | Alianza | - | Atlético Marte | 3:0 | ||||
| Group B | 25/09/2022 | Alianza | - | Once Deportivo | 5:0 | ||||
| Group B | 29/09/2022 | Santa Tecla FC | - | Alianza | 1:2 | ||||
| Group B | 09/10/2022 | Isidro Metapán | - | Alianza | 1:0 | ||||
| Group B | 12/10/2022 | Once Deportivo | - | Alianza | 0:2 | ||||
| Group B | 20/10/2022 | Alianza | - | Santa Tecla FC | 0:1 | ||||
| Quarter-finals | 26/10/2022 | Platense Zacatecoluca | - | Alianza | 1:1 |  |
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| Quarter-finals | 30/10/2022 | Alianza | - | Platense Zacatecoluca | 0:1 |
El Salvador