| 3. Round | 29/07/2019 | Independiente Medellín | - | Atlético Junior | 0:1 | ||||
| 5. Round | 11/08/2019 | Independiente Medellín | - | América de Cali | 4:1 |  |
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| 6. Round | 19/08/2019 | Deportivo Cali | - | Independiente Medellín | 1:0 |  |
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| 7. Round | 23/08/2019 | Independiente Medellín | - | Águilas Doradas | 1:2 | ||||
| 8. Round | 25/08/2019 | Atlético Nacional | - | Independiente Medellín | 5:2 | |
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| 9. Round | 01/09/2019 | Santa Fe | - | Independiente Medellín | 2:0 | |
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| 11. Round | 15/09/2019 | Envigado FC | - | Independiente Medellín | 2:4 | ||||
| 14. Round | 02/10/2019 | Independiente Medellín | - | Deportivo Pasto | 3:1 | ||||
| 16. Round | 11/10/2019 | Independiente Medellín | - | Cúcuta Deportivo | 3:0 | ||||
| 18. Round | 21/10/2019 | Independiente Medellín | - | Alianza Petrolera | 2:0 | ||||
| 19. Round | 24/10/2019 | Atlético Huila | - | Independiente Medellín | 0:1 |
Colombia