| 4. Round | 09/09/2017 | Willem II | - | ADO Den Haag | 1:2 | ||||
| 5. Round | 16/09/2017 | Roda JC Kerkrade | - | Willem II | 1:3 | ||||
| 6. Round | 23/09/2017 | Willem II | - | sc Heerenveen | 1:2 | ||||
| 7. Round | 30/09/2017 | PSV Eindhoven | - | Willem II | 4:0 | ||||
| 8. Round | 15/10/2017 | Willem II | - | FC Twente | 3:1 | ||||
| 9. Round | 20/10/2017 | FC Groningen | - | Willem II | 0:1 | ||||
| 10. Round | 28/10/2017 | Willem II | - | AFC Ajax | 1:3 | ||||
| 11. Round | 04/11/2017 | AZ Alkmaar | - | Willem II | 3:2 | ||||
| 12. Round | 18/11/2017 | Willem II | - | Sparta Rotterdam | 2:2 | ||||
| 13. Round | 25/11/2017 | VVV-Venlo | - | Willem II | 3:3 | ||||
| 15. Round | 08/12/2017 | Willem II | - | NAC Breda | 1:1 | ||||
| 16. Round | 13/12/2017 | Vitesse | - | Willem II | 2:2 | ||||
| 18. Round | 24/12/2017 | AFC Ajax | - | Willem II | 3:1 | ||||
| 20. Round | 28/01/2018 | Willem II | - | AZ Alkmaar | 0:2 | ||||
| 24. Round | 17/02/2018 | ADO Den Haag | - | Willem II | 2:1 | ||||
| 29. Round | 31/03/2018 | Willem II | - | FC Utrecht | 3:2 | ||||
| 30. Round | 06/04/2018 | SBV Excelsior | - | Willem II | 2:1 |  |
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| 31. Round | 15/04/2018 | NAC Breda | - | Willem II | 1:2 |
Netherlands