| 6. Round | 02/02/2022 | Pumas Tabasco | - | Club Celaya | 0:1 | ||||
| 7. Round | 10/02/2022 | Club Celaya | - | Leones Negros | 0:0 | ||||
| 8. Round | 15/02/2022 | Coyotes de Tlaxcala | - | Club Celaya | 0:1 | ||||
| 9. Round | 23/02/2022 | Club Celaya | - | Correcaminos UAT | 1:1 | ||||
| 10. Round | 01/03/2022 | Alebrijes de Oaxaca | - | Club Celaya | 1:0 | ||||
| 11. Round | 08/03/2022 | Club Celaya | - | Atlético Morelia | 2:2 | ||||
| 12. Round | 17/03/2022 | Cimarrones de Sonora | - | Club Celaya | 3:2 | ||||
| 13. Round | 23/03/2022 | Dorados de Sinaloa | - | Club Celaya | 0:2 | ||||
| 14. Round | 26/03/2022 | Club Celaya | - | Tapatío | 5:0 | ||||
| 15. Round | 31/03/2022 | Club Celaya | - | Mineros de Zacatecas | 2:1 | ||||
| 16. Round | 07/04/2022 | TM Fútbol Club | - | Club Celaya | 2:2 | ||||
| 17. Round | 14/04/2022 | Club Celaya | - | Venados FC | 1:0 |  |
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Peru