| 2. Round | 12/09/2021 | AEK Larnaca | - | Omonia Nikosia | 2:1 |  |
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| 3. Round | 20/09/2021 | Omonia Nikosia | - | Doxa Katokopias | 2:1 |  |
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| 6. Round | 17/10/2021 | Omonia Nikosia | - | Apollon Limassol | 1:0 | ||||
| 7. Round | 25/10/2021 | PAEEK | - | Omonia Nikosia | 1:0 | ||||
| 8. Round | 29/10/2021 | Omonia Nikosia | - | Anorthosis Famagusta | 0:1 | ||||
| 10. Round | 21/11/2021 | Omonia Nikosia | - | Aris Limassol | 3:0 | |
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| 12. Round | 05/12/2021 | AEL Limassol | - | Omonia Nikosia | 0:1 | ||||
| 13. Round | 13/12/2021 | Omonia Nikosia | - | AEK Larnaca | 1:1 | ||||
| 11. Round | 26/12/2021 | APOEL Nikosia | - | Omonia Nikosia | 4:2 | |
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| 15. Round | 05/01/2022 | Paphos FC | - | Omonia Nikosia | 1:1 |  |
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| 17. Round | 16/01/2022 | Apollon Limassol | - | Omonia Nikosia | 2:0 | ||||
| 18. Round | 24/01/2022 | Omonia Nikosia | - | PAEEK | 2:1 | ||||
| 19. Round | 29/01/2022 | Anorthosis Famagusta | - | Omonia Nikosia | 1:1 |
Spain
