| 8. Round | 11/09/2021 | Real Santander | - | Barranquilla FC | 1:1 | ||||
| 9. Round | 18/09/2021 | Bogotá FC | - | Real Santander | 1:1 |  |
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| 10. Round | 24/09/2021 | Real Santander | - | Atlético FC | 0:2 |  |
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| 11. Round | 02/10/2021 | Orsomarso SC | - | Real Santander | 3:1 | ||||
| 12. Round | 09/10/2021 | Real Santander | - | Valledupar FC | 1:1 | ||||
| 13. Round | 20/10/2021 | Boyacá Chicó | - | Real Santander | 3:1 | ||||
| 14. Round | 24/10/2021 | Real Santander | - | Fortaleza FC | 1:1 |
Colombia