| 1. Round | 08/07/2022 | Patriotas FC | - | Atlético Junior | 1:0 |  |
|||
| 2. Round | 14/07/2022 | Atlético Junior | - | Atlético Nacional | 3:1 | ||||
| 3. Round | 17/07/2022 | La Equidad | - | Atlético Junior | 0:0 | ||||
| 5. Round | 31/07/2022 | Águilas Doradas | - | Atlético Junior | 1:1 | |
|||
| 6. Round | 08/08/2022 | Atlético Junior | - | Once Caldas | 1:2 | |
|||
| 7. Round | 14/08/2022 | Atlético Junior | - | Independiente Medellín | 4:2 | ||||
| 8. Round | 21/08/2022 | América de Cali | - | Atlético Junior | 2:1 | ||||
| 9. Round | 29/08/2022 | Atlético Junior | - | Deportes Tolima | 2:1 | ||||
| 10. Round | 04/09/2022 | Unión Magdalena | - | Atlético Junior | 2:1 | ||||
| 11. Round | 10/09/2022 | Atlético Junior | - | Deportivo Pereira | 0:0 | |
|||
| 12. Round | 18/09/2022 | Deportivo Pasto | - | Atlético Junior | 2:1 | |
|||
| 14. Round | 26/09/2022 | Alianza Petrolera | - | Atlético Junior | 0:1 | |
|||
| 20. Round | 30/10/2022 | Jaguares de Córdoba | - | Atlético Junior | 0:2 |
Colombia