| 1. Round | 29/01/2008 | Atlas Guadalajara | - | La Paz FC | 2:0 | ||||
| 1. Round | 05/02/2008 | La Paz FC | - | Atlas Guadalajara | 1:0 | ||||
| Group 3 | 22/02/2008 | Atlas Guadalajara | - | Colo-Colo | 3:0 | ||||
| Group 3 | 06/03/2008 | Boca Juniors | - | Atlas Guadalajara | 3:0 | ||||
| Group 3 | 13/03/2008 | Atlas Guadalajara | - | UA Maracaibo | 3:0 | ||||
| Group 3 | 26/03/2008 | UA Maracaibo | - | Atlas Guadalajara | 1:1 | ||||
| Group 3 | 09/04/2008 | Atlas Guadalajara | - | Boca Juniors | 3:1 | ||||
| Group 3 | 23/04/2008 | Colo-Colo | - | Atlas Guadalajara | 1:1 | ||||
| Round of 16 | 30/04/2008 | Lanús | - | Atlas Guadalajara | 0:1 |  |
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| Round of 16 | 07/05/2008 | Atlas Guadalajara | - | Lanús | 2:2 | ||||
| Quarter-finals | 14/05/2008 | Boca Juniors | - | Atlas Guadalajara | 2:2 | ||||
| Quarter-finals | 21/05/2008 | Atlas Guadalajara | - | Boca Juniors | 0:3 |  |
Uruguay