| 1. Round | 13/07/2019 | Guaraní | - | River Plate | 1:3 | ||||
| 2. Round | 20/07/2019 | Libertad | - | Guaraní | 1:0 | ||||
| 3. Round | 28/07/2019 | Guaraní | - | Sportivo Luqueño | 1:3 | ||||
| 6. Round | 18/08/2019 | Deportivo Capiatá | - | Guaraní | 1:2 | ||||
| 7. Round | 24/08/2019 | Guaraní | - | San Lorenzo | 3:1 | ||||
| 8. Round | 01/09/2019 | Guaraní | - | General Díaz | 5:0 | ||||
| 9. Round | 14/09/2019 | Sol de América | - | Guaraní | 0:1 | ||||
| 10. Round | 22/09/2019 | Guaraní | - | Club Olimpia | 1:1 |  |
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| 11. Round | 25/09/2019 | Club Nacional | - | Guaraní | 0:2 | ||||
| 12. Round | 28/09/2019 | River Plate | - | Guaraní | 0:1 | ||||
| 13. Round | 05/10/2019 | Guaraní | - | Libertad | 1:1 |  |
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| 16. Round | 31/10/2019 | Deportivo Santaní | - | Guaraní | 2:1 | ||||
| 17. Round | 24/11/2019 | Guaraní | - | Deportivo Capiatá | 2:1 | ||||
| 20. Round | 01/12/2019 | Guaraní | - | Sol de América | 0:1 | ||||
| 21. Round | 08/12/2019 | Club Olimpia | - | Guaraní | 2:2 | |
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| 22. Round | 15/12/2019 | Guaraní | - | Club Nacional | 0:5 |
Uruguay