| 1. Round | 04/04/2021 | Getafe CF B | - | UD Melilla | 2:2 | ||||
| 2. Round | 11/04/2021 | UD Melilla | - | UD Poblense | 3:2 | ||||
| 4. Round | 25/04/2021 | UD Melilla | - | Las Rozas CF | 0:0 | ||||
| 5. Round | 02/05/2021 | UD Melilla | - | Getafe CF B | 1:1 | ||||
| 3. Round | 05/05/2021 | Atlético Madrid B | - | UD Melilla | 0:2 | ||||
| 6. Round | 09/05/2021 | UD Poblense | - | UD Melilla | 0:0 | ||||
| 7. Round | 16/05/2021 | UD Melilla | - | Atlético Madrid B | 3:0 |  |
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| 8. Round | 23/05/2021 | Las Rozas CF | - | UD Melilla | 2:2 |  |
Panama