| 1. Round | 31/01/2025 | Internacional de Palmira | - | Real Cartagena | 2:0 | ||||
| 2. Round | 09/02/2025 | Real Cartagena | - | Bogotá FC | 5:0 | ||||
| 3. Round | 17/02/2025 | Leones FC | - | Real Cartagena | 1:2 | ||||
| 5. Round | 02/03/2025 | Real Cartagena | - | Boca Juniors de Cali | 3:2 |  |
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| 6. Round | 09/03/2025 | Real Cartagena | - | Real Santander | 2:0 | ||||
| 7. Round | 18/03/2025 | Tigres FC | - | Real Cartagena | 0:0 | ||||
| 9. Round | 29/03/2025 | Barranquilla FC | - | Real Cartagena | 2:2 | ||||
| 4. Round | 04/04/2025 | Real Soacha Cundinamarca | - | Real Cartagena | 3:0 | ||||
| 10. Round | 17/04/2025 | Real Cartagena | - | Patriotas FC | 1:3 |
Colombia