1. Round | 18/07/2021 | Santa Fe | - | Deportivo Cali | 1:2 | ||||
2. Round | 25/07/2021 | Atlético Bucaramanga | - | Santa Fe | 4:3 | ||||
3. Round | 04/08/2021 | Santa Fe | - | Atlético Nacional | 0:1 | ||||
4. Round | 08/08/2021 | Millonarios | - | Santa Fe | 0:1 | ||||
5. Round | 17/08/2021 | Santa Fe | - | La Equidad | 0:2 | ||||
9. Round | 12/09/2021 | Santa Fe | - | Alianza Petrolera | 1:1 | ||||
10. Round | 20/09/2021 | Deportivo Pasto | - | Santa Fe | 0:1 | ||||
11. Round | 25/09/2021 | Santa Fe | - | Envigado FC | 3:1 | ||||
13. Round | 12/10/2021 | Patriotas FC | - | Santa Fe | 0:1 | ||||
14. Round | 18/10/2021 | Santa Fe | - | Millonarios | 0:2 | ||||
15. Round | 25/10/2021 | Atlético Huila | - | Santa Fe | 1:2 | ||||
16. Round | 28/10/2021 | Santa Fe | - | Jaguares de Córdoba | 3:1 | ||||
17. Round | 02/11/2021 | Deportes Quindío | - | Santa Fe | 1:1 | ||||
20. Round | 21/11/2021 | Santa Fe | - | Águilas Doradas | 0:1 |