| 1. Round | 29/07/2021 | TM Fútbol Club | - | Leones Negros | 3:2 | ||||
| 2. Round | 04/08/2021 | Mineros de Zacatecas | - | Leones Negros | 2:1 | ||||
| 3. Round | 13/08/2021 | Leones Negros | - | Dorados de Sinaloa | 0:0 | ||||
| 4. Round | 19/08/2021 | Correcaminos UAT | - | Leones Negros | 2:2 | ||||
| 5. Round | 29/08/2021 | Leones Negros | - | Alebrijes de Oaxaca | 1:1 |
Panama