| 2. Round | 16/01/2022 | Leones Negros | - | Pumas Tabasco | 3:1 |  |
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| 3. Round | 20/01/2022 | Alebrijes de Oaxaca | - | Leones Negros | 1:1 | ||||
| 4. Round | 27/01/2022 | Leones Negros | - | Correcaminos UAT | 0:3 | ||||
| 5. Round | 31/01/2022 | Dorados de Sinaloa | - | Leones Negros | 0:1 | ||||
| 6. Round | 05/02/2022 | Leones Negros | - | Mineros de Zacatecas | 2:3 | ||||
| 7. Round | 10/02/2022 | Club Celaya | - | Leones Negros | 0:0 | ||||
| 1. Round | 14/02/2022 | Cimarrones de Sonora | - | Leones Negros | 2:3 | ||||
| 8. Round | 18/02/2022 | Leones Negros | - | Atlante | 3:1 | ||||
| 9. Round | 23/02/2022 | Leones Negros | - | Venados FC | 0:1 | ||||
| 11. Round | 09/03/2022 | Leones Negros | - | Tepatitlán | 2:1 | ||||
| 10. Round | 20/03/2022 | Coyotes de Tlaxcala | - | Leones Negros | 1:2 | ||||
| 13. Round | 23/03/2022 | Leones Negros | - | CF Monterrey II | 0:0 | ||||
| 14. Round | 27/03/2022 | Atlético Morelia | - | Leones Negros | 0:1 | ||||
| 15. Round | 02/04/2022 | Leones Negros | - | TM Fútbol Club | 1:1 | ||||
| 16. Round | 10/04/2022 | Tapatío | - | Leones Negros | 1:1 | ||||
| 17. Round | 13/04/2022 | Leones Negros | - | Cancún FC | 1:0 |
Panama