| Group B | 18/10/2020 | Boston River | - | Deportivo Maldonado | 5:1 |  |
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| Group B | 24/10/2020 | Fénix | - | Boston River | 2:0 | ||||
| Group B | 08/11/2020 | Boston River | - | River Plate | 0:3 | ||||
| Group B | 11/11/2020 | Danubio | - | Boston River | 0:0 | ||||
| Group B | 22/11/2020 | Peñarol | - | Boston River | 2:0 | ||||
| Group B | 29/11/2020 | Boston River | - | Nacional | 0:1 | ||||
| Group B | 13/01/2021 | Defensor Sporting | - | Boston River | 1:1 |  |
Uruguay