| 8. Round | 20/09/2021 | Managua FC | - | Real Madriz | 1:1 | ||||
| 6. Round | 23/09/2021 | Managua FC | - | Club Deportivo Ocotal | 3:1 |  |
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| 9. Round | 27/09/2021 | CD Walter Ferretti | - | Managua FC | 0:0 | ||||
| 10. Round | 02/10/2021 | Juventus Managua | - | Managua FC | 1:3 | ||||
| 12. Round | 17/10/2021 | Real Estelí FC | - | Managua FC | 1:0 | ||||
| 16. Round | 05/11/2021 | Club Deportivo Ocotal | - | Managua FC | 1:0 | ||||
| 18. Round | 22/11/2021 | Managua FC | - | CD Walter Ferretti | 3:1 |
Nicaragua