| 11. Round | 19/03/2022 | ART Municipal Jalapa | - | Managua FC | 1:0 | ||||
| 13. Round | 06/04/2022 | H&H Export Sébaco | - | Managua FC | 2:0 | ||||
| 14. Round | 10/04/2022 | Managua FC | - | Diriangén FC | 2:3 | ||||
| 15. Round | 14/04/2022 | Club Deportivo Ocotal | - | Managua FC | 1:1 |  |
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| 16. Round | 25/04/2022 | UNAN Managua | - | Managua FC | 0:1 |  |
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| 17. Round | 28/04/2022 | Managua FC | - | Real Madriz | 3:0 | |
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| 18. Round | 02/05/2022 | CD Walter Ferretti | - | Managua FC | 1:0 |
Nicaragua