| 1. Round | 06/08/2005 | San Lorenzo | - | Vélez Sarsfield | 3:2 | ||||
| 2. Round | 14/08/2005 | Estudiantes | - | San Lorenzo | 0:1 | ||||
| 6. Round | 11/09/2005 | Rosario Central | - | San Lorenzo | 0:4 |  |
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| 7. Round | 17/09/2005 | San Lorenzo | - | Lanús | 1:1 | ||||
| 8. Round | 25/09/2005 | Instituto de Córdoba | - | San Lorenzo | 2:0 | ||||
| 9. Round | 01/10/2005 | San Lorenzo | - | Gimnasia de Jujuy | 1:1 | ||||
| 11. Round | 15/10/2005 | Gimnasia de La Plata | - | San Lorenzo | 3:2 | ||||
| 12. Round | 30/10/2005 | San Lorenzo | - | Racing Club | 2:1 | ||||
| 13. Round | 09/11/2005 | Quilmes | - | San Lorenzo | 2:0 | ||||
| 15. Round | 17/11/2005 | River Plate | - | San Lorenzo | 5:1 | ||||
| 16. Round | 22/11/2005 | San Lorenzo | - | Newell's Old Boys | 4:2 | |
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| 17. Round | 25/11/2005 | Banfield | - | San Lorenzo | 5:0 | ||||
| 18. Round | 04/12/2005 | San Lorenzo | - | Colón de Santa Fe | 1:4 | ||||
| 19. Round | 11/12/2005 | Arsenal de Sarandí | - | San Lorenzo | 1:2 |
Paraguay