| 6. Round | 26/08/2018 | Richmond Kickers | - | Louisville City FC | 0:6 |  |
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| 7. Round | 16/09/2018 | Pittsburgh Riverhounds | - | Louisville City FC | 2:2 | ||||
| 7. Round | 19/09/2018 | Penn FC | - | Louisville City FC | 0:3 | ||||
| 7. Round | 23/09/2018 | Louisville City FC | - | Ottawa Fury | 4:0 | ||||
| 7. Round | 30/09/2018 | Atlanta United II | - | Louisville City FC | 1:4 | ||||
| 8. Round | 10/10/2018 | Louisville City FC | - | North Carolina FC | 2:1 |
USA
Guatemala