| 4. Round | 15/02/2022 | Real Cartagena | - | Atlético Huila | 1:1 |  |
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| 5. Round | 20/02/2022 | Atlético Huila | - | Real Santander | 1:1 | ||||
| 6. Round | 28/02/2022 | Atlético FC | - | Atlético Huila | 1:0 | ||||
| 9. Round | 20/03/2022 | Atlético Huila | - | Orsomarso SC | 0:1 | ||||
| 10. Round | 26/03/2022 | Llaneros FC | - | Atlético Huila | 2:1 |
Colombia