| 1. Round | 07/01/2022 | Pumas Tabasco | - | CF Monterrey II | 0:1 | ||||
| 2. Round | 16/01/2022 | Leones Negros | - | Pumas Tabasco | 3:1 | ||||
| 4. Round | 26/01/2022 | Venados FC | - | Pumas Tabasco | 2:2 | ||||
| 6. Round | 02/02/2022 | Pumas Tabasco | - | Club Celaya | 0:1 | ||||
| 13. Round | 23/03/2022 | Pumas Tabasco | - | Cimarrones de Sonora | 2:2 | ||||
| 16. Round | 05/04/2022 | Alebrijes de Oaxaca | - | Pumas Tabasco | 0:0 |
Mexico