| 1. Round | 06/02/2022 | Independiente Petrolero | - | Always Ready | 1:2 |  |
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| 2. Round | 13/02/2022 | Real Tomayapo | - | Independiente Petrolero | 1:1 | ||||
| 3. Round | 20/02/2022 | Independiente Petrolero | - | Bolívar | 1:0 | |
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| 4. Round | 27/02/2022 | Jorge Wilstermann | - | Independiente Petrolero | 1:0 | ||||
| 5. Round | 06/03/2022 | Independiente Petrolero | - | Blooming | 2:3 | |
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| 6. Round | 13/03/2022 | Universitario de Sucre | - | Independiente Petrolero | 1:2 | ||||
| 7. Round | 02/04/2022 | Universitario de Vinto | - | Independiente Petrolero | 2:2 | |
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| 8. Round | 09/04/2022 | Royal Pari | - | Independiente Petrolero | 5:1 | ||||
| 9. Round | 16/04/2022 | Always Ready | - | Independiente Petrolero | 1:1 | |
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| 10. Round | 19/04/2022 | Independiente Petrolero | - | Real Tomayapo | 1:1 | ||||
| 11. Round | 23/04/2022 | Bolívar | - | Independiente Petrolero | 3:1 | ||||
| 13. Round | 08/05/2022 | Independiente Petrolero | - | Universitario de Sucre | 1:0 | ||||
| 15. Round | 15/05/2022 | Independiente Petrolero | - | Universitario de Vinto | 0:0 | ||||
| 16. Round | 21/05/2022 | Independiente Petrolero | - | Royal Pari | 0:0 |
Colombia