| Group A | 07/04/2022 | Independiente Petrolero | - | Emelec | 1:1 | ||||
| Group A | 13/04/2022 | Palmeiras | - | Independiente Petrolero | 8:1 |  |
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| Group A | 26/04/2022 | Independiente Petrolero | - | Deportivo Táchira | 1:2 |  |
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| Group A | 04/05/2022 | Independiente Petrolero | - | Palmeiras | 0:5 | ||||
| Group A | 19/05/2022 | Deportivo Táchira | - | Independiente Petrolero | 3:0 |
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