| 5. Round | 17/10/1948 | Sampdoria | - | Genoa CFC | 5:1 |  |
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| 6. Round | 24/10/1948 | Modena FC | - | Sampdoria | 2:1 | ||||
| 11. Round | 21/11/1948 | US Palermo | - | Sampdoria | 1:1 | ||||
| 13. Round | 05/12/1948 | Sampdoria | - | Lucchese | 5:0 | ||||
| 15. Round | 12/12/1948 | Bologna FC | - | Sampdoria | 1:2 | ||||
| 16. Round | 19/12/1948 | Sampdoria | - | US Livorno | 3:0 | ||||
| 14. Round | 23/12/1948 | Atalanta | - | Sampdoria | 1:5 | |
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| 17. Round | 26/12/1948 | Lazio Roma | - | Sampdoria | 2:0 | ||||
| 20. Round | 09/01/1949 | Sampdoria | - | Inter | 0:4 | ||||
| 24. Round | 06/02/1949 | Genoa CFC | - | Sampdoria | 0:0 | ||||
| 25. Round | 13/02/1949 | Sampdoria | - | Modena FC | 1:1 | ||||
| 26. Round | 20/02/1949 | Juventus | - | Sampdoria | 5:1 | ||||
| 27. Round | 06/03/1949 | Sampdoria | - | Novara Calcio | 1:3 | |
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| 28. Round | 13/03/1949 | US Triestina | - | Sampdoria | 3:1 | ||||
| 33. Round | 20/04/1949 | Sampdoria | - | Atalanta | 4:2 | ||||
| 34. Round | 30/04/1949 | Sampdoria | - | Bologna FC | 1:1 | |
Argentina