2. Round | 12/02/2022 | San Francisco FC | - | Independiente de La Chorrera | 2:0 | ||||
3. Round | 20/02/2022 | Atlético Chiriquí | - | San Francisco FC | 2:1 | ||||
4. Round | 26/02/2022 | San Francisco FC | - | UD Universitario | 0:1 | ||||
5. Round | 05/03/2022 | Herrera FC | - | San Francisco FC | 0:0 | ||||
6. Round | 09/03/2022 | San Francisco FC | - | Árabe Unido | 0:0 | ||||
7. Round | 13/03/2022 | Alianza | - | San Francisco FC | 2:1 | ||||
8. Round | 20/03/2022 | Tauro FC | - | San Francisco FC | 1:0 | ||||
10. Round | 02/04/2022 | San Francisco FC | - | Plaza Amador | 2:2 | ||||
11. Round | 09/04/2022 | Deportivo del Este | - | San Francisco FC | 0:0 |