| 1. Round | 24/01/2021 | Junior Managua | - | Managua FC | 1:3 | ||||
| 2. Round | 28/01/2021 | ART Municipal Jalapa | - | Junior Managua | 1:1 |  |
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| 3. Round | 31/01/2021 | Junior Managua | - | Club Deportivo Ocotal | 0:0 | ||||
| 12. Round | 01/04/2021 | Club Deportivo Ocotal | - | Junior Managua | 2:1 | ||||
| 13. Round | 11/04/2021 | Junior Managua | - | CD Walter Ferretti | 1:1 | ||||
| 16. Round | 29/04/2021 | Real Madriz | - | Junior Managua | 1:2 | |
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| 17. Round | 02/05/2021 | Junior Managua | - | Real Estelí FC | 0:2 | ||||
| 18. Round | 05/05/2021 | Juventus Managua | - | Junior Managua | 2:2 |
Nicaragua