| 5. Round | 05/03/2022 | Cienciano | - | Ayacucho FC | 3:1 | ||||
| 6. Round | 13/03/2022 | Ayacucho FC | - | Deportivo Binacional | 2:3 | ||||
| 7. Round | 20/03/2022 | AD Tarma | - | Ayacucho FC | 0:0 | ||||
| 10. Round | 17/04/2022 | Sport Boys | - | Ayacucho FC | 1:0 | ||||
| 13. Round | 08/05/2022 | Ayacucho FC | - | Mannucci | 2:2 | ||||
| 14. Round | 13/05/2022 | Sporting Cristal | - | Ayacucho FC | 3:2 | ||||
| 15. Round | 22/05/2022 | Ayacucho FC | - | FBC Melgar | 0:1 | ||||
| 17. Round | 20/06/2022 | Ayacucho FC | - | Sport Huancayo | 1:1 | ||||
| 18. Round | 27/06/2022 | Alianza Lima | - | Ayacucho FC | 2:0 |  |
Peru