| 6. Round | 13/02/2022 | Santa Fe | - | Deportivo Pereira | 1:2 | ||||
| 7. Round | 16/02/2022 | Deportes Tolima | - | Santa Fe | 3:0 | ||||
| 9. Round | 01/03/2022 | Patriotas FC | - | Santa Fe | 1:1 | ||||
| 10. Round | 06/03/2022 | Santa Fe | - | Millonarios | 0:3 | ||||
| 11. Round | 17/03/2022 | Deportivo Pasto | - | Santa Fe | 2:4 | ||||
| 13. Round | 29/03/2022 | Atlético Nacional | - | Santa Fe | 2:1 |
Colombia