| 1. Round | 07/07/2022 | Unión Magdalena | - | Once Caldas | 2:2 | ||||
| 2. Round | 13/07/2022 | Alianza Petrolera | - | Unión Magdalena | 0:1 | ||||
| 3. Round | 19/07/2022 | Unión Magdalena | - | Deportes Tolima | 2:1 |  |
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| 4. Round | 23/07/2022 | Deportivo Pasto | - | Unión Magdalena | 1:2 | ||||
| 9. Round | 30/08/2022 | Deportivo Cali | - | Unión Magdalena | 2:2 | ||||
| 10. Round | 04/09/2022 | Unión Magdalena | - | Atlético Junior | 2:1 | ||||
| 11. Round | 10/09/2022 | Cortuluá | - | Unión Magdalena | 1:2 | ||||
| 12. Round | 18/09/2022 | Unión Magdalena | - | Jaguares de Córdoba | 1:0 | ||||
| 13. Round | 22/09/2022 | Águilas Doradas | - | Unión Magdalena | 2:0 | ||||
| 14. Round | 25/09/2022 | Unión Magdalena | - | Santa Fe | 0:2 |  |
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| 15. Round | 04/10/2022 | Patriotas FC | - | Unión Magdalena | 3:1 | |
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| 16. Round | 10/10/2022 | Unión Magdalena | - | Independiente Medellín | 0:2 | ||||
| 17. Round | 14/10/2022 | Atlético Junior | - | Unión Magdalena | 1:1 | ||||
| 18. Round | 16/10/2022 | Unión Magdalena | - | Deportivo Pereira | 2:0 | |
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| 19. Round | 22/10/2022 | La Equidad | - | Unión Magdalena | 4:1 | ||||
| 20. Round | 30/10/2022 | Unión Magdalena | - | América de Cali | 0:0 |
Colombia