| 3. Round | 31/01/2021 | Chinandega | - | Managua FC | 1:1 |  |
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| 4. Round | 04/02/2021 | Club Deportivo Ocotal | - | Chinandega | 0:0 | ||||
| 5. Round | 06/02/2021 | Junior Managua | - | Chinandega | 2:1 | ||||
| 8. Round | 18/02/2021 | Chinandega | - | ART Municipal Jalapa | 1:1 | ||||
| 11. Round | 14/03/2021 | Real Estelí FC | - | Chinandega | 4:1 | ||||
| 15. Round | 25/04/2021 | Real Madriz | - | Chinandega | 2:0 |
Nicaragua