| 2. Round | 22/01/2025 | CSD Municipal | - | Achuapa | 2:1 |  |
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| 3. Round | 27/01/2025 | Xelaju MC | - | CSD Municipal | 1:1 | ||||
| 8. Round | 12/02/2025 | Deportivo Guastatoya | - | CSD Municipal | 0:2 | ||||
| 9. Round | 15/02/2025 | CSD Municipal | - | Comunicaciones | 2:1 | ||||
| 10. Round | 24/02/2025 | Deportivo Marquense | - | CSD Municipal | 0:0 | ||||
| 11. Round | 02/03/2025 | CSD Municipal | - | Cobán Imperial | 2:1 | |
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| 13. Round | 09/03/2025 | Achuapa | - | CSD Municipal | 2:1 | |
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| 14. Round | 29/03/2025 | CSD Municipal | - | Xelaju MC | 1:0 | ||||
| 15. Round | 02/04/2025 | CSD Municipal | - | Antigua GFC | 1:2 | |
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| 17. Round | 09/04/2025 | CSD Municipal | - | Deportivo Xinabajul | 2:1 | ||||
| 18. Round | 13/04/2025 | Deportivo Mixco | - | CSD Municipal | 1:1 | ||||
| 19. Round | 17/04/2025 | CSD Municipal | - | Deportivo Guastatoya | 1:0 | ||||
| 20. Round | 21/04/2025 | Comunicaciones | - | CSD Municipal | 1:0 | ||||
| 21. Round | 23/04/2025 | CSD Municipal | - | Deportivo Marquense | 0:0 | ||||
| 22. Round | 27/04/2025 | Cobán Imperial | - | CSD Municipal | 2:1 |
Guatemala