| 3. Round | 01/08/2021 | Independiente Medellín | - | Atlético Junior | 0:0 | ||||
| 4. Round | 09/08/2021 | Atlético Junior | - | Deportes Tolima | 0:0 | ||||
| 5. Round | 15/08/2021 | Jaguares de Córdoba | - | Atlético Junior | 1:1 | ||||
| 14. Round | 18/10/2021 | Atlético Junior | - | Jaguares de Córdoba | 2:1 | ||||
| 17. Round | 01/11/2021 | Atlético Junior | - | Deportivo Pasto | 2:1 |  |
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| 19. Round | 18/11/2021 | Atlético Junior | - | La Equidad | 1:0 |
Colombia