| 1. Round | 28/07/2021 | Municipal Pérez Zeledón | - | Jicaral | 1:1 | ||||
| 2. Round | 31/07/2021 | Municipal Pérez Zeledón | - | Deportivo Saprissa | 0:3 | ||||
| 3. Round | 07/08/2021 | AD San Carlos | - | Municipal Pérez Zeledón | 1:1 | ||||
| 4. Round | 12/08/2021 | CS Herediano | - | Municipal Pérez Zeledón | 1:0 | ||||
| 5. Round | 15/08/2021 | Municipal Pérez Zeledón | - | Guadalupe | 1:1 | ||||
| 6. Round | 17/08/2021 | Municipal Grecia | - | Municipal Pérez Zeledón | 1:0 | ||||
| 10. Round | 11/09/2021 | Sporting FC | - | Municipal Pérez Zeledón | 1:1 | ||||
| 11. Round | 15/09/2021 | Municipal Pérez Zeledón | - | LD Alajuelense | 1:0 | ||||
| 12. Round | 18/09/2021 | Jicaral | - | Municipal Pérez Zeledón | 3:0 | ||||
| 13. Round | 27/09/2021 | Deportivo Saprissa | - | Municipal Pérez Zeledón | 3:0 | ||||
| 14. Round | 03/10/2021 | Municipal Pérez Zeledón | - | AD San Carlos | 1:1 |
Costa Rica